To give up an office or position, often formally.
M.E. resignen "give up, surrender, abandon; relinquish," from O.Fr. resigner "renounce, relinquish," from L. resignare "to check off, cancel, give back, give up," from → re- "opposite" + signare "to make an entry in an account book," literally "to mark;" → sign.
The act of resigning.
Verbal noun from → resign.